CNS Dopamine Transmission Mediated by Noradrenergic Innervation

CNS dopamine transmission mediated by noradrenergic innervation.

The presynaptic source of dopamine in the CA1 field of dorsal hippocampus is uncertain due to an anatomical mismatch between dopaminergic terminals and receptors. We show, in an in vitro slice preparation from C57BL/6 male mice, that a dopamine (DA) D1 receptor (D1R)-mediated enhancement in glutamate synaptic transmission occurs following release of endogenous DA with amphetamine exposure. It i...

Functional development of the ovarian noradrenergic innervation.

A substantial fraction of the noradrenergic innervation targeting the mammalian ovary is provided by neurons of the celiac ganglion. Although studies in the rat have shown that noradrenergic nerves reach the ovary near the time of birth, it is unknown how the functional capacity of this innervation unfolds during postnatal ovarian development. To address this issue, we assessed the ability of t...

Noradrenergic Innervation of Cat Spinal Locomotor Neurons

Noradrenaline (NA) is a strong modulator and/or activator of spinal locomotor 21 networks. Thus, noradrenergic fibers likely contact neurons involved in generating locomotion. 22 The aim of the present study was to investigate the noradrenergic innervation of functionally23 related, locomotor-activated neurons within the thoraco-lumbar spinal cord. This was 24 accomplished by immunohistochemica...

Noradrenergic inhibition of midbrain dopamine neurons.

Receptors that couple to phosphoinositide hydrolysis, which include metabotropic glutamate receptors (mGluRs) and muscarinic receptors, are known to either activate or inhibit the activity of dopamine cells depending on the pattern of receptor activation. Transient activation of alpha1 adrenoceptors with norepinephrine (NE) resulted in an outward current in midbrain dopamine neurons recorded in...

Pulmonary noradrenergic innervation of rat and monkey: a comparative study.